Preservative Free Eye Gel in single dose containers for reduction of the elevated intraocular pressure in patients with ocular hypertension or chronic open angle glaucoma.


Tiopex is the only once daily, preservative-free timolol

Although Tiopex is lower strength than other timolol eye drops (0.1% compared to 0.25% or 0.5%) and is dosed once daily it provides non-inferior IntraOcular Pressure (IOP) control compared to 0.5% aqueous drops dosed twice daily over 24 hours1 and after 12 weeks.2,3

Patients switched from preserved 0.5% aqueous timolol twice daily to Tiopex have significantly lower adverse effects.3

Due to the lower strength and once daily dose there is a 10-fold reduction in timolol administered and 90% less systemic absorption compared with timolol 0.5% BID.4

Tiopex features a ‘Fluid gel’ vehicle (carbomer and polyvinyl alcohol) which enhances residence time and provides additional ocular comfort without significant blurring.5,6

1 Mayer H et al. Ophthalmologica 1996;210:101-3
2 Rouland JF et al. Ophthalmologica 2002;216(6):449-54
Lester, M. et al. J. Ocular Pharm. and Thearpeutics 2014; vol. 30, No. 6: 476-481
Uusitalo H et al. Acta Ophthalmol Scand 2005;83(6):723-8
Shedden, A.H. Chibret Int. J. Ophthalmol. 1994; 10: 32-6
6 Pouliquen, P. J. Fr. Ophtalmol. 1999; 22(8): 903-13

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