For healthcare professionals

SPC Patient Information

Introducing Vevizye®

Preservative free badge.

- Vevizye contains ciclosporin 1mg/mL in a preservative-free, phosphate-free, multi-dose eye drop formulation1

- Ciclosporin is a calcineurin inhibitor with anti-inflammatory and immunosuppressant properties1

Vevizye is indicated for the treatment of moderate to severe dry eye disease (keratoconjunctivitis sicca) in adult patients, which has not improved despite treatment with tear substitutes1. The water-free vehicle has specific properties which reduce friction, enhance spreading (thereby contributing to efficacy) and enable Vevizye to be preservative-free and phosphate-free.1.

Vevizye has been shown to have a fast onset of action with significant improvements in total Corneal Fluorescein Staining (tCFS) in 2 weeks2 which are maintained over 12 months3. After 1 month over 70% of patients had more than 3 grades improvement in tCFS scores2.

Studies have shown that Vevizye is well tolerated with high patient satisfaction and low side effect profile3. Installation site pain was the most commonly reported at 7.9%.1

Key Features

  • Rapid onset of action, within two weeks2
  • Preservative-free, phosphate-free formulation1
  • Multi-dose bottle
  • Well tolerated for long term use3

How to use

Recommended dosage for adults (including the elderly): one drop, twice daily to be applied to each eye approximately 12 hours apart. If a dose is missed, treatment should be continued with the next dose as normal. Patients should be advised not to instil more than one drop in each eye.

There is no relevant use of ciclosporin in the paediatric population for the indication of dry eye disease.

Vevizye can be used for up to 4 weeks after first opening of the bottle. The bottle should be kept tightly closed when not in use.

Do not store above 25 °C.

Do not freeze or refrigerate.

Pack contents

One box contains 1 x 5mL multi-dose bottle with 2mL fill.

Pricing

Prescription Only Medicine

NHS price: £66.53 for one bottle

PIP code: 436-6605

References

1. Vevizye® SmPC. September 2024.

2. Akpek E, et al. JAMA Ophthalmol. 2023;1415:459–466.

3. Wirta DL, et al. Cornea. 2024;446:692–700.

Page last updated: 16th December 2025